Nucleophilic Dearomatization of Activated Pyridines
نویسندگان
چکیده
منابع مشابه
Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums.
NHC-catalyzed nucleophilic dearomatization of alkyl pyridiniums has been achieved to generate 1,4-dihydropyridines with high enantioselectivity. This is a rare example of catalytic, asymmetric addition of a nucleophile to the activated pyridinium that prefers C-4 functionalization leading to the 1,4-dihydropyridine with high selectivity.
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4-(Dimethylamino)pyridine (4-DMAP, 1) is well known as a catalyst for the esterification of alcohols by acid anhydrides and for various other synthetically useful transformations involving acyl transfer. 2] Its catalytic potential was first discovered by the groups of Litvinenko and Steglich in the late 1960s and its synthetic utility and that of its congeners, including polymeric variants, hav...
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An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.
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ژورنال
عنوان ژورنال: Catalysts
سال: 2018
ISSN: 2073-4344
DOI: 10.3390/catal8120632